Losing Control in Controlled Settings: Preclinical Human Research on Impulsivity Within the Context of Addiction

Abstract Purpose of Review Impulsivity has long been recognized as a risk factor for addiction. The mechanisms through which impulsivity increases remain unclear, hindering development effective impulsivity-targeted addiction treatments. Preclinical human research is ideally placed to isolate these because the experimental control afforded by laboratory. This review summarizes recent preclinical studies on and that are focused alcohol use or food consumption/overeating. Recent Findings emergence laboratory paradigms specifically modeling impulsive consumption promising development, especially capable manipulating test causation. Collectively, this evidence highlights importance reward in impulsivity-related consumption. Summary suggest interventions may be enhanced widening current focus disinhibition-related include drive. models could utilized pilot candidate pharmacological psychosocial therapeutics causal mechanisms, informing next generation treatment.